BML-SE278-0020 20 µg Product Specification
Alternative Name: ICA512, Protein tyrosine phosphatase IA2
MW: ~58.8 kDa
Purity: ≥90% (SDS-PAGE)
Formulation: Liquid. In 25mM TRIS-HCl, pH 8.0, containing 75mM sodium chloride, 0.05% Tween-20, 50% glycerol, 2mM EDTA, 1mM dithiothreitol and 10mM glutathione.
Source/Host: Produced in E. coli. The catalytic domain of human PTP-IA2 (aa 693-970) is fused at the N-terminus to a GST-tag.
Application: Study of enzyme kinetics and regulation, dephosphorylation of target substrates, and inhibitor screening.
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
Miscellaneous/General: IA2, together with IAR, form a subgroup of receptor-like protein tyrosine phosphatases. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. It is highly expressed in neuroendocrine tissues.
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