Application: For use in deubiquitinylating enzyme assays and linear polyubiquitin binding studies.
Short Term Storage: -20°C
Long Term Storage: -20°C
Use/Stability: Stable for at least 12 months after receipt when stored at -20°C.
Handling: After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Miscellaneous/General: Linear polyubiquitin chains, in which the C-terminal Gly of one ubiquitin is conjugated to the N-terminal Met of an adjacent ubiquitin, have been shown to be assembled in vitro by the E3 ligase complex LUBAC. Ubiquitin binding domains (UBDs) with a preference for linear polyubiquitin have been identified.
A possible role for linear polyubiquitin modification in NFκB pathway activation has been reported and thus an important role for linear polyubiquitinylation in cellular processes in addition to that of lysine-linked polyubiquitin protein conjugation is suggested.
Concentration: 1mg/ml, except Ub4 and Ub6 which are supplied at 0.5mg/ml
Purity: ≥90% (SDS-PAGE)
Formulation: Liquid. In 50mM TRIS, pH 8.0, containing 50mM sodium chloride.
Source/Host: Produced in E. coli.
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