BML-C121-0050 50 mg
BML-C121-0010 10 mg
Highly selective allosteric potentiator of the M1 muscarinic acetylcholine receptor (mAChR). Reduces the concentration of ACh required to activate M1 up to 129-fold and displays no potentiation, agonism or antagonism activity at other mAChRs at concentrations up to 100µM. Reverses scopolamine-induced memory deficits and increases blood flow to the cerebral cortex in mouse models. M1 activators slow the progression of Alzheimers disease. Induces β-arrestin recruitment to M1.
At 100µM, it activated M1 in the absence of ACh to ca. 50% maximal response. At 10µM, it reduced the concentration of ACh required to displace radioligand by 45-fold. In vivo experiments were carried out in mice at 15 or 20mg/kg. The compound is cell permeable, brain penetrant and orally active.
Product Specification
Alternative Name: 1-(4-Methoxybenzyl)-4-oxo-1,4-dihydro-3-quinoline carboxylic acid
Formula: C18H15NO4
MW: 309.3
Purity: ≥98% (TLC)
Appearance: White solid.
Source/Host: Synthetic.
Solubility: Soluble in DMSO (10mg/ml).
Shipping: AMBIENT
Long Term Storage: Ambient
Use/Stability: Stable for at least 1 year after receipt when stored at room temperature. Stock solutions are stable for for up to 3 months at -20°C.
订购电话:021-51870956
在线QQ：470003480
快来www.haoranbio.com体验在线订购给您带来的快捷和方便吧!