BML-EI266-0025 25 mg
BML-EI266-0005 5 mg
Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.
Product Specification
Alternative Name: L-663,536, 3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid, Na
Formula: C27H33ClNO2S·Na
MW: 494.0
Purity: ≥99% (TLC)
Appearance: White solid.
CAS: 118414-82-7
Solubility: Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).
Long Term Storage: Ambient
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Prepare fresh solutions daily.
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