| Catalogue Number | ANT-183 |
| Synonyms | BMP-2, BMP2A. |
| Type | Mouse Anti Human Monoclonal. |
| Introduction | BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. |
| Background | Bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor beta(TGF-f3) superfamily.
It can induce bone formation and regeneration during early embryonic development.
BMP-2 is synthesized as large precursor molecule firstly and the mature protein is secreted by proteolytic cleavage. Natural mature BMP-2 monomer has 114 amino acid residues and has no biological function unless it turns into dimmer. It's assumed that mature BMP-2 forms a cysteine knot with seven conserved cysteine residues. The active form can consist of a dimmer of two identical proteins or a heterodimer of two related bone morphogenetic proteins. |
| Source | The BMP-2 antibody was prepared by affinity chromatography from ascites of BALB/c mouseinoculated by a hybridoma cell that secreted anti- BMP-2 monoclonal antibodies. |
| Host | Mouse. |
| Purity | Greater than 90%, analysed by reducing SDS-PAGE. |
| Formulation | Samples are lyophilized in sterile PBS buffers. |
| Storage conditions | Stable at -20°C for two years. For long-term storage, keep aliquot samples at -70°C. Once reconstituted, samples are stable at 4°C for several weeks. |
| Application | Applied in detections of antigen or antibody: ELISA or Western blot. For indirect ELISA, dilute antibody solution by 1: 250. |
| Usage | Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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