Replaces Prod. #: ALX-270-209
Antitumor reagent. Topoisomerase II inhibitor. Induces apoptosis by FasL. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cancer cells.
Product Specification
Alternative Name: 4-Desmethylepipodophyllotoxin 9-(4,6-O-ethylidene)-β-D-glucopyranoside, VP-16-213
Formula: C29H32O13
MW: 588.6
Purity: ≥97% (HPLC)
Appearance: White to off-white powder.
CAS: 33419-42-0
MI: 14: 3886
RTECS: KC0190000
Source/Host: Semisynthetic derivative of podophyllotoxin.
Solubility: Soluble in DMSO, dimethyl formamide, ethyl ether or chloroform:methanol (1:1); slightly soluble in methanol or acetone; insoluble in water.
Shipping: AMBIENT
Long Term Storage: +20°C
Use/Stability: Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C. 
Hazard: MAY BE CARCINOGENIC.
TOXIC.
Handling: Protect from light and moisture.