Product Specification
Formula: C43H69NO12
MW: 792
Purity: ≥95% (HPLC)
Appearance: Off-white solid
CAS: 11011-38-4
Source/Host: Isolated from Streptomyces sp.
Solubility: Soluble in DMSO (25mg/ml)
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Hazard: HARMFUL.
Replaces Prod. #: ALX-380-005
Ascomycin is a close structural analog of FK506 and is a potent immunosuppressant. It binds to FKBP (FK506-binding protein) and suppresses its proline rotamase activity. The ascomycin-FKBP complex inhibits calcineurin, a type 2B phosphatase.