The calpains are calcium-dependent cysteine proteases that are widely expressed in mammalian systems. Both m-calpain (calpain II) and μ-calpain (calpain I) are composed of two subunits (80 kDa and 30 kDa). Whereas the small subunit is common to both enzymes, the larger catalytic subunits are different and exhibit distinct calcium ion requirements. m-Calpain requires millimolar levels of Ca2+, and μ-calpain is active at micromolar concentrations of Ca2+. In addition to the ubiquitously expressed m- and μ-calpains, some tissue-specific calpains have been identified.
The calpains appear to serve multiple physiological roles.
Product Specification
Alternative Name: μ-Calpain
Purity Detail: Chromatographically purified.
Formulation: Liquid. In buffer.
Clone: 15C10
Isotype: Mouse IgG1
Immunogen: Human placenta calpain.
Specificity: Recognizes human, mouse, rat and cow calpain I.
Application: ELISA
Immunoprecipitation
Western Blot
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C