Replaces Prod. #: ALX-380-030
Macrolide antibiotic that acts as a potent and selective inhibitor of vacuolar-type H+-ATPase (V-type) (IC50=004-0.4nmol/mg). Valuable tool for distinguishing among different types of ATPases. Inhibitor of endosomal acidification.¨Blocks lysosomal cholesterol trafficking in macrophages. Blocks pH regulation in brain cells.
Product Specification
Formula: C35H58O9
MW: 622.8
Purity: ≥95% (HPLC)
Appearance: Colorless oil.
CAS: 88899-55-2
Solubility: Soluble in 100% ethanol, methanol or DMSO.
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Hazard: TOXIC.
Handling: Protect from light.