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Member of the tyrphostin family of tyrosine kinase inhibitors. Selective inhibitor of the PDGF receptor kinase (IC50=20µM) vs. the EGF receptor kinase (IC50=820µM). Inhibits PDGF-induced mitogenesis in human bone marrow fibroblasts.
Product Specification
Alternative Name: Tyrphostin AG 370, Tyrphostin B7, 2-Amino-4-(1H-indol-5-yl)-1,1,3-tricyanobuta-1,3-diene
Formula: C15H9N5
MW: 259.3
Purity: ≥99%
Appearance: Yellow solid.
CAS: 134036-53-6
Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (2mg/ml, warm).
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling: Protect from light.
Store tightly sealed in the dark.