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Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). It possesses Ki values in the nanomolar range against the gelatinases (14nM for MMP-2; 600nM for MMP-9), but in the micromolar range against other metalloproteinases (206µM for MMP-1, 15µM for MMP-3, 96µM for MMP-7, and 4µM for ADAM17/TACE). This inhibitor has also been used in vitro, in vivo, and in tissue culture. In vivo, it is metabolized to an even more potent gelatinase inhibitor.
Product Specification
Formula: C15H4O3S2
MW: 306.4
Purity: ≥98% (TLC)
Appearance: White solid
CAS: 292605-14-2
Solubility: Soluble in DMSO (at least 30mM) and 100%ethanol.
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C