Inhibits the trypsin-like, chymotrypsin-like and caspase-like (PGPH) activity in isolated proteasomes and in living cells by covalent modification of the amino-terminal threonine of the catalytically active β subunits. The vinyl sulfone acts as a Michael acceptor for soft nucleophiles such as thiols, leading to the formation of a covalent bond, while being resistant to attack by free thiols, which can cause inactivation of other classes of protease inhibitors.
Product Specification
MW: 722.2
Purity: 99%
Sequence: NIP-(Leu)3-vinyl sulfone
Long Term Storage: -20°C 
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