Sensitive fluorogenic substrate for cathepsin K (Km=8µM, kcat/Km=4 x 10 M-1s-1). This substrate is also cleaved by cathepsin B, F, L, L2/V, S. Z-LR-AMC is also cleaved by malaria parasite cysteine proteases falcipain-1, -2, -3, berghepain, and vivapain-2, -3. Ex.: 365nm, Em.: 440nm, although the following Ex/Em can also be used: 355,380/450,460. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).
Product Specification
Alternative Name: Z-Leu-Arg-AMC, Cathepsin K substrate (fluorogenic)
MW: 578.7
Purity: 97%
Sequence: Z-Leu-Arg-AMC•HCl[Z=Cbz=Benzyloxycarbonyl;AMC=7-amino-4-methylcoumarin]
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
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