Amino Acid Sequence

His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr

Components

H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl

Other Notes

Lyophilized from 0.1% TFA in H2O

Application

Glucagon (GCG) has been used-
• as a component of hormone stock solution for preserving full biological activity of heart tissues obtained from male Sprague-Dawley rats^[1]
• as an infusion in phases II and III fasting king penguins to study the various lipolytic, metabolic, and hormonal responses^[2]

Biochem/physiol Actions

Glucagon (GCG) produces elevation in contractility and the frequency of contraction in heart muscles. It activates PI3K (phosphoinositide 3-kinase) and thus, elevates glucose utilization by heart muscles.^[1] In multiple mammals, though not humans, this peptide induces lipolysis, and is the major lipolytic hormone in birds. It also induces gluconeogenesis and glycogenolysis in mammals and birds.^[2]

General description

Glucagon (GCG) peptide is secreted in response to insulin from pancreatic islets α-cells.^[1]

Properties

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