四环素
- Sigma-Aldrich
- 一般经销商
- 进口
- 美国
- 现货
- 全国
- 2
- 1
英文名：Tetracycline CAS号：60-54-8 产品别名：4-(二甲基氨基)-1,4,4A,5,5A,6,11,12A-八氢-3,6,10,12,12A-五羟基-6-甲基-1,11-二羰基-2-萘甲酰胺;四环素碱;水合四环素,;
四环素
Tetracycline
≥98.0% (NT)
产品描述
Biochem/physiol Actions
Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.
Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.
Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.
包装
25g, 100g
General description
Chemical structure: tetracycline
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Store under inert gas. Keep in a dry place.
性质
| Related Categories | Antibacterial, Antibiotics A to Z, Antibiotics T-Z,Antibiotics by Application, Chemical Structure Class, |
| biological source | synthetic |
| InChI Key | OFVLGDICTFRJMM-WESIUVDSSA-N |
| assay | ≥98.0% (NT) |
| form | powder |
| optical activity | [α]20/D −230±5°, c = 1% in methanol |
| impurities | 4-11% water |
| (Residue on ignition) | ≤0.5% |
| color | yellow to yellow-orange |
| mp | 172-174 °C (dec.) |
| solubility | 95% ethanol: soluble 12.5 mg/mL |
| Mode of action | protein synthesis | interferes |
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| storage temp. | 2-8°C |
| Gene Information | human ... CYP1A2(1544), TERT(7015) |
美国sigma-aldrich是全球最大的化工试剂生产商，Sigma-Aldrich 是一个生物/ 化学试剂领先的高科技企业。我们的生化试剂，有机化学试剂和试剂盒广泛应用于基因组学研究，生物科技，药物研发，疾病诊断和化工生产上。我们的客户遍及生命科学公司，大学，研究机构，医院以及工业部门。其客户遍及160个国家地区，在35个国家有分支机构，雇员超过6,800人。
【Sigma-Aldrich 中国代理商：联硕生物科技有限公司】
Sigma-Aldrich is a leading Life Science and High Technology company. Our chemical and biochemical products and kits are used in scientific research, including genomic and proteomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical, diagnostic and other high technology manufacturing.
