NS 8593 hydrochloride
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英文名：NS 8593 hydrochloride 存储条件：2-8°C CAS号：875755-24-1 NS8593 盐酸盐NS8593 hydrochloride≥98% (HPLC), powder安全技术说明书别名: :
NS8593 盐酸盐
NS8593 hydrochloride
≥98% (HPLC), powder
别名: : N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride
经验分子式（希尔表示法） C17H17N3 · HCl
分子量 299.80
PubChem Substance ID 329818415
产品描述
包装
5, 25 mg in glass bottle
Biochem/physiol Actions
The compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reversibly inhibited recombinant SK3-mediated currents (human and rat SK3) with potencies around 100 nM. NS8593 did not inhibit 125I-apamin binding. NS8593 decreased the calcium sensitivity by shifting the activation curve for Ca2+to the right, only slightly affecting the maximal Ca2+-activated SK current. NS8593 inhibited all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+. NS8593 did not affect the calcium-activated potassium channels of intermediate and large conductance (hIK and hBK channels, respectively). NS8593-mediated inhibition was prevented in the presence of a high concentration of the positive modulator NS309.
Features and Benefits
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
法律信息
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
性质
| Related Categories | Bioactive Small Molecule Alphabetical Index, Ion Channels, Monovalent Ion Channels, N, Potassium Channel Modulators, |
| InChI Key | VWEKCDTXUUPBNA-PFEQFJNWSA-N |
| assay | ≥98% (HPLC) |
| form | powder |
| solubility | DMSO: >10 mg/mL |
| H2O: insoluble | |
| storage temp. | 2-8°C |
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