N-甲基-D-天冬氨酸
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英文名：N-Methyl-D-aspartic acid 存储条件：RT CAS号：6384-92-5 产品别名：(R)-2-(甲基氨基)丁二酸(R)-2-(Methylamino)succinic acid; NMDA N-甲基-D-天冬
| 货号 | 规格 | CAS号 | 包装 | 操作 |
|---|---|---|---|---|
| M3262-25MG | ≥98% (TLC) | 6384-92-5 | 25mg | 询底价 |
N-甲基-D-天冬氨酸
N-Methyl-D-aspartic acid
≥98% (TLC), solid
别名: (R)-2-(Methylamino)succinic acid NMDA
经验分子式（希尔表示法） C5H9NO4
分子量 147.13
Beilstein Registry Number 1724431
MDL number MFCD00004226
PubChem Substance ID 24277987
eCl@ss 32160406
产品描述
包装
1, 5 g in poly bottle
25, 100, 250 mg in poly bottle
Application
N-Methyl-D-aspartic acid has been used to induce N-methyl-d-aspartic acid (NMDA) toxicity, cultures of retinal cells were supplemented with NMDA.[1][4]
Biochem/physiol Actions
Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy.
N-Methyl-D-aspartic acid (NMDA) plays a crucial role in release of luteinizing hormone and PRL (prolactin) in the pituitary gland and GnRH (gonadotropin releasing hormone) in the hypothalamus.[2][3] It acts as a specific agonist for NMDA type glutamate receptors.[3]
Features and Benefits
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
General description
N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.[2]
法律信息
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
性质
| Related Categories | Excitatory Amino Acids, NMDA Agonists,Neuroscience, Neurotransmission, Neurotransmitters, |
| InChI Key | HOKKHZGPKSLGJE-GSVOUGTGSA-N |
| assay | ≥98% (TLC) |
| form | solid |
| color | white |
| Gene Information | human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907) rat ... Gria1(50592), Grik1(29559), Grin2a(24409) |
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