耗材描述

• 分子式 CH₃OC₆H₄COCH₂Br
• 分子量229.07
• Beilstein号 743112
• EC号 220-118-8
• MDL号 MFCD00000201
• PubChem编号 24847233

属性

熔点	69-71°C
溶解性	Soluble in DMSO, water (partly miscible), most organic solvents, and methanol.
存贮条件	储存温度2-8℃
密度	1.4480

描述

应用	A cell-permeable, covalent and potent protein tyrosine phosphatase inhibitor.
产品介绍	PTP inhibitor II is a cell-permeable, covalent and potent PTP (protein tyrosine phosphatase) inhibitor. The compound acts by binding the catalytic domain of the SH2 domain-containing phosphatase SHP-1(DSH2). PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Ki = 128 μM and Ki = 43 μM respectively). The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm. PTP inhibitors have demonstrated enhanced clonogenic survival, mutagenesis and cell growth. PTP inhibitors can also be useful for probing signal transduction pathways as well as drugs for treatment of PTP-related diseases. PTP Inhibitor II is an inhibitor of PTP1B and SH-PTP1.
别名	4-甲氧基-α－溴代苯乙酮; ω-溴-4-甲氧基苯乙酮;4-甲氧基苯甲酰基甲基溴;对甲氧基-α-溴代苯乙酮;α-溴-4-甲氧基苯乙酮;4'-甲氧基苯甲酰甲基溴;alpha-溴-4-甲氧基苯乙酮;4-Methoxyphenacyl bromide;ω-Bromo-4-methoxyacetophenone;4-(Bromoacetyl)anisole;α-Bromo-4'-methoxyacetophenone;4'-Methoxyphenacyl Bromide;alpha-Bromo-4-methoxyacetophenone;Bromomethyl 4-methoxyphenyl ketone; 2-Bromo-1-(4-methoxyphenyl)ethanone

Reaxys-RN	743112
标识符号	GHS05, GHS07
信号词	Danger
危害声明	H314,H335
警示性声明	P261,P280,P305+P351+P338,P310
个人防护设备	Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
WGK德国	3
风险声明 (欧洲)	R34;R36/37
安全声明（欧洲）	S26;S27;S28;S36/37/39;S45
危害码（欧洲）	C
UN代码	3261

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