耗材描述

• 分子式 C₁₄H₁₇N₃O₃S
• 分子量307.37

属性

溶解性	25°C: DMSO
存贮条件	储存温度2-8℃

描述

产品介绍	Hydroxyfasudil(HA1100)是Fasudil的代谢物，对ROCK1和ROCK2的IC50分别为120nM和170nM，还是血管舒张剂。
生化机理	Fasudil (1-10 μM) and hydroxyfasudil (0.3-10 μM) significantly prevented endothelin-induced cardiomyocyte hypertrophy [2]. Hydroxyfasudil significantly attenuated serotonin (IC)-induced vasoconstriction of SA (-7 +/- 1% vs. 2 +/- 1%, p < 0.01). Coronary I/R significantly impaired coronary vasodilation to acetylcholine after I/R (SA, p < 0.05; and A, p < 0.01 vs. before I/R) and L-NMMA further reduced the vasodilation, whereas hydroxyfasudil completely preserved the responses.
别名	HA-1100;HA 1100;HA1100;HA-1100;HA 1100;HA1100; 5-((hexahydro-1h-1,4-diazepin-1-yl)sulfonyl)-1(2h)-isoquinolinone;

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