耗材描述

• 分子式
• 分子量460.57
• Beilstein号
• EC号
• MDL号
• PubChem编号

属性

溶解性	DMSO 92 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C

描述

备注	PHA-848125 is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7. Phase 2.
生化机理	PHA-848125 is an orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and thropomyosin receptor kinase A (TRKA), with potential antineoplastic activity.
别名	Milciclib;N,1,4,4-tetramethyl-8-(4-(4-methylpiperazin-1-yl)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide;Milciclib;N,1,4,4-tetramethyl-8-(4-(4-methylpiperazin-1-yl)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

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