| 应用 |
An apoptosis inducer. |
| 产品介绍 |
Idarubicin HCl是Idarubicin的盐酸盐形式，是蒽环类抗生素，抑制DNA拓扑异构酶II (topo II)，作用于MCF-7细胞，IC50为3.3 ng/mL。 |
| 备注 |
Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL. |
| 生化机理 |
Idarubicin Hydrochloride is the hydrochloride salt preparation of Idarubicin (IDA), an anthracycline and an analog of daunorubicin. IDA is rapidly metabolized to its 13-dihydroderivative (Idarubicinol) which is more stable than the parent form. This compound has been reported to trigger apoptotic cell death via enhancement of Fas and caspase-3/caspase-7 expression. In experiments, where cells were exposed to IDA, reactive oxygen species (ROS) were produced which induced DNA strand breaks and prevented DNA polymerase reaction. Idarubicin Hydrochloride is an inhibitor of Topo II α. Idarubicin Hydrochloride is also a substrate of CYP2D6 and CYP2C9. |
| 别名 |
盐酸依达比星; 去甲氧基柔红霉素盐酸盐;Idamycin;Zavedos;4-demethoxydaunorubicin;Idamycin;Zavedos;4-demethoxydaunorubicin;(7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione hydrochloride |
