耗材描述

• 分子式 C₁₇H₁₅N₇O₂
• 分子量349.35

属性

溶解性	DMSO 0.28 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度 2-8°C

描述

产品介绍	CP-466722是一种有效的，可逆的ATM抑制剂，不影响ATR，且抑制细胞中同类的PI3K或PIKK。
备注	CP-466722 is a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.
生化机理	CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase. The compound CP466722 disrupts ATM-dependent checkpoint cell cylce events, and reverses ATM-dependent substrate phosphorylation and downstream signaling events following exposure to ionizing radiation.
别名	CP466722;1-(6,7-二甲氧基-4-喹唑啉基)-3-(2-吡啶基)-1H-1,2,4-三唑-5-胺;CP466722; CP-466722;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine

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