| 产品介绍 |
PJ34 HCl 是PJ34的盐酸盐形式，是一种PARP抑制剂，EC50为20 nM，同等有效作用于PARP1/2。 |
| 备注 |
PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2. |
| 生化机理 |
PARP Inhibitor VIII, PJ34 is a cell-permeable, water-soluble phenanthridinone derivative which inhibits of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). It is believed to be up to 10,000 times more potent than 3-aminobenzamide which has an EC = 200 μM. Studies have shown that PARP over-activation can lead to NAD depletion and consequent necrosis, thus inducing inflammatory conditions in many diseases. It has been observed that at lower concentrations, PARP Inhibitor VIII, PJ34 displays antioxidant activity. Studies conducted in vitro on stroke models indicate that this compound has neuroprotective functions. PARP Inhibitor VIII, PJ34 is an inhibitor of PARP-1 and PARP-2. |
| 别名 |
PJ 34 盐酸盐; N-(6-氧代-5,6-二氢菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺盐酸盐;PJ-34 hydrochloride; PJ 34 hydrochloride;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride;2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride |
