耗材描述

• 分子式 C₂₂H₂₂FN₃O₃
• 分子量395.43

属性

溶解性	DMSO 79mg/mL; Water <1 mg/mL; Ethanol 31 mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	AZD2461是新型PARP抑制剂，能够避免由Pgp介导的olaparib抗性。
备注	AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.
生化机理	AZD2461 has an 80-fold increased Mdr1b expression on Olaparib-resistant KB1P tumor T6-28, without inhibition of Pgp. AZD2461 induces loss of 53BP1 expression in mice with KB1P tumors with short-term treatment. Long-term AZD2461 treatment is well tolerated and doubled the median relapse-free survival.
别名	4-(4-氟-3-((4-甲氧基哌啶-1-基)羰基)苄基)酞嗪-1(2H)-酮;AZD2461;AZD 2461;4-(4-fluoro-3-((4-methoxypiperidin-1-yl)carbonyl)benzyl)phthalazin-1(2h)-one

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