耗材描述

• 分子式 C₁₈H₂₁N₃O₂
• 分子量311.38

属性

折光率	1.57
溶解性	DMSO 100 mg/ml Ethanol 10 mg/ml
存贮条件	储存温度2-8℃
密度	1.1200

描述

应用	A novel selective agonist at ERRβ and ERRγ
产品介绍	DY131(GSK 9089)是ERRβ和ERRγ选择性激动剂，对ERRα，ERα和ERβ的活性极低。
生化机理	DY131, a selective ERRγ agonist, could potentiate the ERRγ-induced growth inhibition in LNCaP- ERRγ and DU145- ERRγ cells in a dose-dependent manner compared with respective parental cells. DY131 inhibited the growth of the ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells. DY131 had no effect on the structurally related receptors ERRα or the estrogen receptors alpha and beta (ERalpha/beta). DY131 appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists.
别名	GSK 9089;DY-131;DY 131;GSK9089;GSK-9089;GSK 9089;DY-131;DY 131;GSK9089;GSK-9089;4-hydroxybenzoic acid 2-((4-(diethylamino)phenyl)methylene)hydrazide;

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