耗材描述

• 分子式 C₁₉H₁₆N₆O₄S
• 分子量424.43
• Beilstein号
• EC号 MFCD09955343
• MDL号
• PubChem编号

属性

溶解性	DMSO ≥12mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
存贮条件	储存温度-20°C

描述

应用	A specific ETAR antagonist
产品介绍	Zibotentan (ZD4054)是口服活性的内皮素A（ETA）受体特异性拮抗剂，IC50为21 nM。
生化机理	Zibotentan (ZD4054) is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). Zibotentan is capable of inhibiting or reducing the multitude of effects that are evoked by ET-1 activation of the ETA receptor and which promote tumor survival, growth and progression. Zibotentan (ZD4054) treatment produced significant inhibition of tumor growth in ovarian and breast xenografts.
别名	ZD4054;ZD-4054;ZD 4054; N-(3-甲氧基-5-甲基-2-吡嗪基)-2-(4-(1,3,4-恶二唑-2-基)苯基)-3-吡啶磺酰胺;;ZD4054;ZD-4054;ZD 4054; n-(3-methoxy-5-methyl-2-pyrazinyl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-3-pyridinesulfonamide

RTECS

UT7937700

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