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分子式 C26H28Cl2N4O4 分子量531.43 Beilstein号 EC号 265-667-4 MDL号 MFCD00058579 PubChem编号 24278176 属性 敏感性 对热敏感 溶解性 Soluble in DMS
| 货号 | CAS号 | 操作 |
|---|---|---|
| K129737-1g | 65277-42-1 | 询底价 |
| K129737-25g | 65277-42-1 | 询底价 |
| K129737-5g | 65277-42-1 | 询底价 |
| K129737-100g | 65277-42-1 | 询底价 |
耗材描述
- 分子式 C26H28Cl2N4O4
- 分子量531.43
- Beilstein号
- EC号 265-667-4
- MDL号 MFCD00058579
- PubChem编号 24278176
属性
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in DMSO (20 mg/mL warm), ethanol (20 mg/mL warm), chloroform, water (<1 mg/mL), and methanol |
| 存贮条件 | 储存温度2-8℃ |
描述
| 应用 | An inhibitor of CYP proteins, thromboxane synthetase, and 5-LO |
| 产品介绍 | Ketoconazole is an imidazole-containing small molecule inhibitor of cytochrome P-450-dependent steps in the biosynthesis of steroid hormones; also inhibits TXA Synthase (thromboxane synthetase) and 5-LO (5-lipoxygenase) activity. Ketoconazole exhibits antimetastatic, antineoplastic, and antipsoriatic activity. Inhibition of 5-LO (5-lipoxygenase) by Ketoconazole interrupts arachidonic acid -derived leukotriene production, which was correlated to a suppression of leukotriene-mediated anaphylactic bronchoconstriction in guinea pigs. Ketoconazole is described as reducing platelet cellular levels of thromboxane A2, suppressing thromboxane A2-mediated increase of microvascular permeability in response to ischemia insults. Ketoconazole produces an antiandrogen effect through inhibition of adrenocorticoid biosynthesis, suppressing the adrenal secretion of androgens and attenuating cortisol response. Ketoconazole is an inhibitor of CYP17A1, CYP3A4 and CYP3A5 |
| 备注 | Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. |
| 别名 | Nizoral, Extina, Xolegel, Kuric;1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone;Nizoral, Extina, Xolegel, Kuric;1-(4-(4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone |
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