耗材描述

• 分子式 C₉H₁₆Br₂N₅O₄P
• 分子量449.04
• Beilstein号
• EC号
• MDL号
• PubChem编号

属性

溶解性	DMSO : 94 mg/mL (209.34 mM; Need ultrasonic and warming)
存贮条件	储存温度-20°C

描述

应用	An H460 and HT29 cell growth inhibitor
产品介绍	Evofosfamide (TH-302) 是一种缺氧 (hypoxia) 激活前药，缺氧 (N2) 和常氧 (21% O2) 环境下，IC50 分别为 10 μM 和 1000 μM。
备注	TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 me
生化机理	TH-302 is a newly developed antineoplastic drug which represents a potential new class of tumor selective hypoxia-activated prodrugs (HAPs).
别名	TH 302;TH302;N,N'-双(2-溴乙基)二氨基膦酸 (1-甲基-2-硝基-1H-咪唑-5-基)甲酯;TH 302;TH302;Evofosfamide;N,N′-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester

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