| 应用 |
双氯芬酸钠已被用于：
· 辐射防护潜力研究
· 确定增溶剂及其胶束加合物的基本粘度和流体动力学值
· 作为顺序注射分析系统中双氯芬酸的电位滴定和荧光测定的标准品
· 抑制II期药物代谢酶（DME），以研究播娘蒿种子的乙醇提取物对I期和II期DME的抑制作用 |
| 产品介绍 |
Diclofenac Sodium是非选择性COX抑制剂，作用于绵羊COX-1和COX-2， IC50分别为60和220 nM。 |
| 备注 |
Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. |
| 生化机理 |
Diclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac. Hydrolysis of aceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against Cox (cyclooxygenase), generates diclofenac, an inhibitor of both Cox-1 and Cox-2. Oxidation of diclofenac produces the metabolite 4'-hydroxy diclofenac which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing antiinflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9 |
| 别名 |
2-[(2,6-二氯苯基)氨基]-苯乙酸钠;
二氯苯胺苯乙酸钠;
双氯灭痛钠;双氯芬酸钠;
双氯胺苯乙酸钠;双氯灭痛;
双氯芬酸钠盐 ;;Solaraze; Ecofenac;2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt; Sodium 2-(2,6-dichloroanilino)phenylacetate |
