Paroxetine hydrochloride hemihydrate-分析测试百科网

Paroxetine hydrochloride hemihydrate

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：2
近期咨询：1

分子式 C19H20FNO3.HCl 分子量374.83 属性熔点 137-139 °C 旋光率 -90°C 溶解性 Soluble in DMSO (25 mg/ml), chloroform, and methanol. Insolu

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上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
P129711-1g	110429-35-1	询底价
P129711-5g	110429-35-1	询底价

耗材描述

分子式 C₁₉H₂₀FNO₃.HCl
分子量374.83

属性

熔点	137-139 °C
旋光率	-90°C
溶解性	Soluble in DMSO (25 mg/ml), chloroform, and methanol. Insoluble in water
存贮条件	储存温度 2-8°C

描述

应用	A highly potent and selective serotonin (5-HT) uptake inhibitor
产品介绍	Paroxetine HCl, a phenylpiperidine derivative, is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity (Ki = 05 nM). In vitro paroxetine competitively inhibits the uptake of 5-HT by rat hypothalamic and cortical synaptosomes with only very weak inhibitory effects on SLC6A2 (noradrenaline) uptake and DAT (dopamine) uptake. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors. Other experiments have shown Paroxetine HCl to inhibit NOS (nitric oxide synthase) and also to be both a substrate and an inhibitor of CYP2D6 (cytochrome isoenzyme P450 2D6).
备注	Paroxetine is an antidepressant drug of the SSRI type.
生化机理	Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant.
别名	(3S,4R)-(-)-3-[(1,3-苯并二恶茂-5-基氧)甲基]-4-(4-氟苯基)哌啶盐酸盐;盐酸帕罗西汀半水合物;(3S,4R)-(-)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine Hydrochloride Hemihydrate;Paxil; Seroxat; BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate

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