Amisulpride
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分子式 C17H27N3O4S 分子量369.48 Beilstein号 EC号 275-831-7 MDL号 MFCD00866691 PubChem编号 24890689 属性 敏感性 对热、湿度和光线敏感 溶解性 Soluble in
| 货号 | CAS号 | 操作 |
|---|---|---|
| A129432-1g | 71675-85-9 | 询底价 |
| A129432-250mg | 71675-85-9 | 询底价 |
| A129432-50mg | 71675-85-9 | 询底价 |
耗材描述
- 分子式 C17H27N3O4S
- 分子量369.48
- Beilstein号
- EC号 275-831-7
- MDL号 MFCD00866691
- PubChem编号 24890689
属性
| 敏感性 | 对热、湿度和光线敏感 |
| 溶解性 | Soluble in water (partly), dichloromethane, chloroform, DMSO (50 mM), 1eq. HCl (25 mM), methanol, and ethanol (74 mg/ml at 25 °C). |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | A selective D2DR and D3DR inhibitor. |
| 备注 | Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. |
| 生化机理 | Amisulpride is a selective, potent D2DR and D3DR inhibitor. (Ki values are 2.8 and 3.2 nM respectively for human D2DR and D3DR and > 1000 nM for human D1DR, D4DR and D5DR.) Amisulpride exhibits selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2DR/D3DR at higher doses. Amisulpride interacts with limbic D2-like receptors . |
| 别名 | 阿米舒必利; 4-氨基-N-[(1-乙基-2-吡咯烷基)甲基]-5-(乙基磺酰基)-2-甲氧基苯甲酰胺;4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-ethylsulfonyl-2-methoxybenzamide;DAN-2163;Deniban;DAN 2163; DAN2163; Solian |
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