TPCA-1
面议
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分子式 C12H10FN3O2S 分子量279.29 MDL号 MFCD09037541 属性 溶解性 DMSO 56 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 存贮条件 储存温度-
| 货号 | CAS号 | 操作 |
|---|---|---|
| T126861-100mg | 507475-17-4 | 询底价 |
| T126861-25mg | 507475-17-4 | 询底价 |
| T126861-5mg | 507475-17-4 | 询底价 |
耗材描述
- 分子式 C12H10FN3O2S
- 分子量279.29
- MDL号 MFCD09037541
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A potent inhibitor of IKKβ (IKK-2) |
| 产品介绍 | TPCA-1是IKK-2选择性抑制剂，IC50为17.9 nM，对IKK-1有22倍以上的选择性，对其它激酶则有超过550倍的选择性。 |
| 备注 | TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. |
| 生化机理 |
TPCA-1 is potent, selective inhibitor of IκB kinase-2 (IKK-2) (IC50 = 17.9 nM) that displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. TPCA-1 inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-κB nuclear localization. TPCA-1 reduces the severity and onset of collagen-induced arthritis; anti-inflammatory. |
| 别名 | TPCA 1;5-(4-氟苯基)-2-脲基噻吩-3-甲酰胺;GW683965;GW683965A;5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide |
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