耗材描述

• 分子式 C₃₃H₃₂N₄O₄
• 分子量548.63

属性

溶解性	DMSO ≥106mg/mL Water <1.2mg/mL Ethanol ≥42mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	ICG-001能拮抗Wnt/β-catenin/TCF介导的转录，并特异地与CBP结合，IC50为3 μM。
生化机理	ICG-001 has no effect on the related reporter construct, FOPFLASH, which contains mutated TCF sites. After treatment with 25μM of ICG-001 for 8 hours, SW480 cell reduces the steady-state levels of Survivin and Cyclin D1 RNA and protein, both of which can be up-regulated by β-catenin. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells
别名	ICG 001;ICG001;(6S,9aS)-六氢-6-((4-羟基苯基)甲基)-8-(1-萘基甲基)-4,7-二氧代-N-(苯甲基)-2H-吡嗪并(1,2-a)嘧啶-1(6H)-甲酰胺;ICG 001;ICG001;(6s,9as)-hexahydro-6-((4-hydroxyphenyl)methyl)-8-(1-naphthalenylmethyl)-4,7-dioxo-n-(phenylmethyl)-2h-pyrazino(1,2-a)pyrimidine-1(6h)-carboxamide

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