Iloperidone-分析测试百科网

Iloperidone

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：4
近期咨询：0

分子式 C24H27FN2O4 分子量426.48 属性熔点 118-120°C 溶解性 DMSO 27 mg/mL Water <1 mg/mL Ethanol 4 mg/mL 存贮条件储存温度-20°C //decorateT

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
I125279-5g	133454-47-4	询底价
I125279-1g	133454-47-4	询底价
I125279-250mg	133454-47-4	询底价
I125279-50mg	133454-47-4	询底价

耗材描述

分子式 C₂₄H₂₇FN₂O₄
分子量426.48

属性

熔点	118-120°C
溶解性	DMSO 27 mg/mL Water <1 mg/mL Ethanol 4 mg/mL
存贮条件	储存温度-20°C

描述

应用	A dopamine (D2) and serotonin (5HT2) receptor antagonist
产品介绍	Iloperidone (伊潘立酮; HP 873) 是D2/5-HT2受体拮抗剂，可作用于精神分裂症。
生化机理	Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Iloperidone targets a selective set of dopamine, serotonin and also norepinephrine receptor subtypes. Like similar atypical antipsychotics, Iloperidone has higher affinity for the 5-HT2A receptor (Ki < 10 nM) than for the D2 receptor (Ki = 10–100) nM). Iloperidone has high affinity for dopamine D3 (Ki < 10 nM) and lower affinity for other serotonin or dopamine subtypes. Unlike most atypical antipsychotics, Iloperidone also has high affinity for norepinephrine alpha1 receptors (Ki < 10 nM) which may contribute to the drug’s efficacy on mood and cognition.
别名	伊潘立酮;Fanapt;HP 873;Zomaril;1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

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