Terbinafine HCl
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分子式 C21H25N·HCl 分子量327.89 MDL号 MFCD00145430 属性 沸点 417.9° C at 760 mmHg 熔点 214℃ 溶解性 DMSO 66 mg/mL Water <1 mg/mL Ethan
| 货号 | CAS号 | 操作 |
|---|---|---|
| T129278-500g | 78628-80-5 | 询底价 |
| T129278-100g | 78628-80-5 | 询底价 |
| T129278-1g | 78628-80-5 | 询底价 |
| T129278-25g | 78628-80-5 | 询底价 |
| T129278-5g | 78628-80-5 | 询底价 |
耗材描述
- 分子式 C21H25N·HCl
- 分子量327.89
- MDL号 MFCD00145430
属性
| 沸点 | 417.9° C at 760 mmHg |
| 熔点 | 214℃ |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies. |
| 产品介绍 | Terbinafine盐酸盐是抗真菌化合物，可杀灭皮肤癣菌和双相型真菌，抑制白色念珠菌。 |
| 生化机理 | Terbinafine hydrochloride is a synthetic allylamine antifungal, which is highly active against dermatophytes, mold, other basic fungi, and some strains of yeast. Terbinafine hydrochloride is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch, inhibiting ergosterol synthesis at the stage of squalene epoxidation (IC50 = 30 nM for C. albicans). Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. At 90-120 ?M, Terbinafine exhibits anti-tumor and anti-angiogenic activity by inducing cell cycle arrest at the G0/G1 stage in COLO 205 tumor cells and human vascular endothelial cells. |
| 别名 | 特比萘芬盐酸盐;盐酸特比萘酚;反-N-(6,6-二甲基-2-庚烯-4-炔基)-N-甲基-1-萘基甲胺盐酸盐;(E)-N-(6,6-二甲基-2-庚烯-4-炔基)-N-甲基-1-萘甲胺盐酸盐;(E)-N-(6,6-二甲基庚-2-烯-4-炔基)-N-甲基-1-萘甲胺盐酸盐;Terbinafine hydrochloride; trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine Hydrochloride; (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine monohydrochloride |
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