Sulfasalazine
面议
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分子式 C18H14N4O5S 分子量398.39 Beilstein号 356241 EC号 209-974-3 MDL号 MFCD00057363 属性 熔点 260-265 °C 敏感性 对光敏感 溶解性 Soluble in DMS
| 货号 | CAS号 | 操作 |
|---|---|---|
| S129986-5g | 599-79-1 | 询底价 |
| S129986-100g | 599-79-1 | 询底价 |
| S129986-25g | 599-79-1 | 询底价 |
耗材描述
- 分子式 C18H14N4O5S
- 分子量398.39
- Beilstein号 356241
- EC号 209-974-3
- MDL号 MFCD00057363
属性
| 熔点 | 260-265 °C |
| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in DMSO (100 mg/ml), dichloromethane, ethanol (1:2900), methanol (1:1500), aqueous sodium bicarbonate, sodium hydroxide solutions, and 1 M NH4OH (50 mg/ml). Insoluble in water. |
描述
| 应用 | An inhibitor of of GSH-H-transferase and NF-kB activation and an apoptosis inducer |
| 产品介绍 | Sulfasalazine 是一种磺胺剂，是Mesalazine的衍生物，主要用作抗炎剂。 |
| 备注 | Sulfasalazine is a sulfa agent and a derivative of mesalazine used primarily as an anti-inflammatory agent. |
| 生化机理 | Sulfasalazine is an antiinflammatory agent that inhibits GSH-H-transferase. Sulfasalazine largely inhibits NF-κB activation and induces apoptosis in T-lymphocytes. The compound also engages neutrophil apoptosis that can be abrogated by Tyr-K inhibitors, PKA inhibitors, or antioxidants. Sulfasalazine is shown to inhibit basic fibroblast growth factor-induced endothelial cell chemotaxis. Sulfasalazine is an inhibitor of TNFα and an activator of PPARγ. |
| 别名 | 水杨酸偶氮磺胺吡啶;磺胺偶氮吡啶;柳氮磺胺吡啶;5-[对-(2-吡啶胺磺酰基)苯]偶氮水杨酸 ;柳氮磺吡啶;2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic acid; 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid; Salicylazosulfapyridine;Azulfidine; NSC 667219 |
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