| 应用 |
A selective inhibitor of eIF-2α used to study ER stress-induced apoptosis |
| 产品介绍 |
Salubrinal是一种选择性的eIF2α 脱磷酸作用抑制剂，可以抑制ER应激介导的细胞凋亡，EC50约为15 μM。 |
| 备注 |
Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM. |
| 生化机理 |
Salubrinal is a cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to protect cells from endoplasmic reticulum (ER) stress-induced apoptosis (EC50~15μM) in PC12 cell lines induced with the protein glycosylation inhibitor tunicamycin, and brefeldin A, which causes ER stress by blocking ER-to-Golgi vesicle transport. Salubrinal is a potentially useful agent to study mechanisms of ER stress-induced apoptosis. |
| 别名 |
沙鲁胺;（2E）-3-苯基-N- [2,2,2-三氯-1 - [[（8-喹啉基氨基）硫代甲基]氨基]乙基] -2-丙烯酰胺
;(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide |
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