| 应用 |
A synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses. |
| 产品介绍 |
Pidotimod是一种合成的二肽分子，对适应性和先天性免疫反应都有生物学免疫活性。对动物和人的样本进行体外研究发现Pidotimod对适应性和先天性免疫反应都有很好的活性，这一结论也在体内实验中得到了确认。这些活性已经应用到临床，在减轻儿童上呼吸道和尿道感染复发率上效果良好。在成人呼吸道感染复发的抑制上也有同样效果 |
| 备注 |
Pidotimod is an immunostimulant. |
| 生化机理 |
Pidotimod is a synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses. This compound has been shown to induce dendritic cell maturation and up-regulate the expression of HLA-DR and co-stimulatory molecules CD83 and CD86, which are integral to communication with adaptive immunity cells. Pidotimod has also been shown to stimulate dendritic cells to release pro-inflammatory molecules such as MCP-1 and TNF-α cytokines, and to inhibit thymocyte apoptosis caused by a variety of apoptosis inducing molecules. |
| 别名 |
匹多莫德; 匹多替莫;(R)-3-[[(S)-5-氧-2-吡咯烷基]羰基]-1,3-噻唑啉-4-羧酸;(R)-3-[[(S)-5-Oxo-2-pyrrolidinyl]carbonyl]-1,3-thiazolidine-4-carboxylic Acid ;(4R)-3-{[(2S)-5-oxopyrrolidin-2-yl]carbonyl}-1,3-thiazolidine-4-carboxylic acid |
