| 应用 |
An Oct-4 activator which increases mRNA expression of Oct-4, Sox-2, Nanog, and Tet1 |
| 产品介绍 |
OAC1是转录因子Oct4活化剂，提高iPSC的重编程效率和编程过程中的加速。 |
| 备注 |
OAC1 (Oct4-activating compound 1) can enhance the efficiency of reprogramming. |
| 生化机理 |
OAC-1 is an Oct-4 activator which enhances and accelerates iPSC reprogramming in the presence of 4F (Oct-4, Sox-2, c-Myc and GKLF) by ~20-fold (relative to 4F by itself). OAC-1 upregulates mRNA expression of Oct-4, Sox-2 and Nanog, as well as Tet1. It has shown no effects, however, on the p53-p21 pathway or Wnt-β-catenin signaling. |
| 别名 |
OAC-1；Oct4-activating Compound 1；N-1H-吡咯并[2,3-c]吡啶-5-基苯甲酰胺;OAC-1；Oct4-activating Compound 1；N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide |
