应用 |
An ATP-competitive inhibitor of PI 3-kinase γ. |
产品介绍 |
AS-604850是一种选择性的,ATP竞争性的PI3Kγ抑制剂,IC50为250 nM,作用于PI3Kγ比作用于PI3Kδ/β选择性高80倍以上,作用于PI3Kγ比作用于PI3Kα选择性高18倍。 |
备注 |
AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα. |
生化机理 |
AS-604850 is a potent, cell permeable and ATP-competitive inhibitor of PI 3-kinase γ (PI(3)Kγ). AS-604850 also exhibits selectivity over other PI 3-kinase isoforms. AS-604850 is an inhibitor of PI 3-kinase and PI 3-kinase p55 γ, PI 3-kinase p110 α and PI 3-kinase p85 α. |
别名 |
AS 604850; 5-[(2,2-二氟-1,3-苯并二恶茂-5-基)亚甲基]噻唑烷-2,4-二酮; 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione ;PI3Kγ inhibitor;AS 604850 |