CHIR-99021-分析测试百科网

CHIR-99021

面议

品牌：阿拉丁
厂商性质：生产商
产地类别：国产
产地：上海
货期：现货
服务地域：全国
规格：2
近期咨询：1

分子式 C22H18Cl2N8 分子量465.34 属性溶解性 Soluble in DMSO (10 mg/ml), water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at

上海阿拉丁生化科技股份有限公司

上海阿拉丁生化科技股份有限公司

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货号	CAS号	操作
C125082-5mg	252917-06-9	询底价
C125082-25mg	252917-06-9	询底价

耗材描述

分子式 C₂₂H₁₈Cl₂N₈
分子量465.34

属性

溶解性	Soluble in DMSO (10 mg/ml), water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C., Soluble in DMSO (10 mg/ml), water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C.
存贮条件	储存温度-20°C

描述

应用	A compound that acts as potent, ATP-competitive & highly selective GSK-3 inhibitor
产品介绍	CHIR-99021 (CT99021)是GSK-3α和β抑制剂，IC50分别为10 nM和6.7 nM，比对CDC2，ERK2及其他激酶的抑制性强500倍。
生化机理	GSK-3 Inhibitor XVI is a cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). CHIR99021 exhibits little to no activity toward 46 other enzymes (IC50 >8.8 μM against 20 kinases and Ki ≥5 μM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 μM).
别名	CT99021;CHIR99021;CHIR 99021;CT-99021;6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基]乙基氨基]吡啶-3-甲腈CT99021;CHIR99021;CHIR 99021;CT-99021;6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile

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