应用 |
A selective PI 3-kinase p110γ inhibitor. |
产品介绍 |
AS-252424是一种新型,有效的PI3Kγ抑制剂,IC50为30 nM,作用于PI3Kγ比作用于PI3Kα选择性高30倍,对PI3Kδ/β具有低的抑制活性。 |
备注 |
AS-252424 is a novel, potent PI3Kγ inhibitor with IC50 of 30 nM with 30-fold selectivity for PI3Kγ than PI3Kα, and low inhibitory activity towards PI3Kδ/β. |
生化机理 |
AS-252424 is a potent and selective PI 3-kinase p110γ inhibitor (IC50 = 33 nM) shown to be selective for class IB PI 3-kinase-mediated cellular effects. AS-252424 also prevents C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50 of 0.23 μM. AS-252424 is an inhibitor of Casein Kinase and PI 3-kinase p110 α. |
别名 |
AS 252424; 5-[[5-(4-氟-2-羟基苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮;5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;AS 252424 |