唑来膦酸单水合物
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分子式 C5H10N2O7P2·H2O 分子量290.10 Beilstein号 EC号 MDL号 MFCD08448695 PubChem编号 属性 敏感性 对热、湿度和光线敏感 溶解性 Soluble in water (7 mg/ml
| 货号 | CAS号 | 操作 |
|---|---|---|
| Z140117-5g | 165800-06-6,118072-93-8 | 询底价 |
| Z140117-1g | 165800-06-6,118072-93-8 | 询底价 |
耗材描述
- 分子式 C5H10N2O7P2·H2O
- 分子量290.10
- Beilstein号
- EC号
- MDL号 MFCD08448695
- PubChem编号
属性
| 敏感性 | 对热、湿度和光线敏感 |
| 溶解性 | Soluble in water (7 mg/ml), 0.1N NaOH, methanol (0.12 mg/ml at 25 °C), and ethanol (0.13 mg/ml at 25 °C). |
| 存贮条件 | 储存温度2-8°C |
描述
| 应用 | A highly potent bisphosphonate and activator of PKC. |
| 产品介绍 | Zoledronic acid(CGP 42446; ZOL 446)一水合物是PKC活化剂，能诱导多发性骨髓瘤细胞系凋亡和抑制hFOB细胞增殖。 |
| 生化机理 | Zoledronic acid monohydrate, also known as cgp 42'446, is a heterocyclic bisphosphonate that is considered to have the highest potency of bisphosphonates for suppression of increased bone resorption and has been used in several osteoporosis studies. The compound has been observed to be more effective than pamidronate. Zoledronic acid has been used in studies investigating mesothelioma. Zoledronic acid monohydrate is an inhibitor of ASM and FDPS and an activator of PKC. |
| 别名 | 唑来膦酸单水合物;唑来磷酸一水化合物;1-羟基-2-(1-咪唑基)乙烷-1,1-二磷酸P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate;Zoledronate monohydrate;[1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate;1-Hydroxy-2-(1-imidazolyl)ethane-1,1-diphosphonic Acid Monohydrate;CGP 42446 monohydrate;CGP42446A monohydrate;ZOL 446 monohydrate |
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