| 应用 |
A specific and selective inhibitor of TGF-β type I ALK receptors and Smad3. |
| 产品介绍 |
SB431542是一种有效的，选择性的ALK5抑制剂，IC50为94 nM，对ALK5的作用比对p38、 MAPK和其他激酶强100倍。 |
| 备注 |
SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases. |
| 生化机理 |
SB 431542 is a small molecule that acts as a specific and selective inhibitor of TGFβ RI, ACTR-IB and ACTR-IC (transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, 5, and 7). Renal carcinoma studies have demonstrated that SB 431542 is a selective inhibitor of Smad3 phosphorylation (IC50= 94nM) and TGF-β-1 collagen induced lα1 (col Iα1). It has been reported that SB 431542 does not affect the JNK, ERK, or p38 MAP kinase pathways. SB 431542 has been shown to suppress TGF-β induced growth stimulation in MG63 cells, inhibit the motility and proliferation of glioma cells, and block the phosphorylation and translocation of SMADs. |
| 别名 |
SB 431542; 4-[4-(3,4-亚甲二氧基苯基)-5-(2-吡啶基)-1H-咪唑-2-基]苯甲酰胺;SB 431542; SB431542; 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide;4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide;4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide |
