盐酸四环素
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分子式 C22H24N2O8·HCl 分子量480.90 Beilstein号 3844873 EC号 200-593-8 MDL号 MFCD00078142 PubChem编号 属性 熔点 223°C 敏感性 对光、热及空气敏感 溶解性
| 货号 | CAS号 | 价格 | 操作 |
|---|---|---|---|
| T140622-25g | 64-75-5 | 面议 | 询底价 |
| T140622-500g | 64-75-5 | 面议 | 询底价 |
| T140622-100g | 64-75-5 | 面议 | 询底价 |
| T105493-100g | 64-75-5 | 面议 | 询底价 |
| T105493-25g | 64-75-5 | 面议 | 询底价 |
耗材描述
- 分子式 C22H24N2O8·HCl
- 分子量480.90
- Beilstein号 3844873
- EC号 200-593-8
- MDL号 MFCD00078142
- PubChem编号
属性
| 熔点 | 223°C |
| 敏感性 | 对光、热及空气敏感 |
| 溶解性 | Soluble in water, dimethyl sulfoxide, methanol and ethanol. Insoluble in ether and hydrocarbons. |
| 存贮条件 | 储存温度-20°C，充氩保存 |
| 密度 | 1.1770 |
描述
| 应用 |
作用模式: 靠阻止胺酰基-tRNA至核糖体30S亚单位上阻止蛋白的合成。 抗菌谱:革兰氏阴性和阳性细菌。 阻断模式: 细胞壁渗透性缺失。 |
| 产品介绍 | Tetracycline Hydrochloride belongs to a family of broad-spectrum antibiotics that inhibit protein synthesis in bacteria by blocking the binding of aminoacyl-tRNA to the bacterial ribosome and has been used in a variety of root canal studies. In tick-borne encephalitis virus (TBEV) studies, tetracycline hydrochloride increased the concentrations of sIL-6R, IL-1RA, sTNFR1 and decreased the levels of TNF-α. Studies show that tetracycline can induce cold shock response and enhance expression of P450 proteins. |
| 生化机理 |
Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action. Mode of Resistance: The effects are inactivated via a loss of cell wall permeability. Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria. |
| 别名 | 四环素 盐酸盐2-naphthacenecarboxamid |
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