应用 |
The aminonucleoside portion of the antibiotic puromycin. |
产品介绍 |
Puromycin Aminonucleoside (3'-Amino-3'-deoxy-N6,N6-dimethyladenosine) is the aminonucleoside portion of the antibiotic puromycin. It is a puromycin analog which does not inhibit protein synthesis or induce apoptosis. Used in the study of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and NOx metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome has been studied. Used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability |
生化机理 |
Puromycin aminonucleoside is used to study human glomerular disease by inducing damage of murine glomerular podocytes1 and is used to study glomerular function and morphology |
别名 |
博罗霉素氨基核苷;3′-Amino-3′-deoxy-N6,N6-dimethyladenosine;9-(3-Amino-3-deoxy-beta-D-ribofuranosyl)-6-(dimethylamino)-9H-purine; Aminonucleoside; Aminonucleoside puromycin;PANS |