耗材描述

• 分子式 C₂₁H₁₇ClN₂O₃
• 分子量380.82
• Beilstein号
• EC号 263-687-8
• MDL号 MFCD00012664
• PubChem编号

属性

熔点	235°C
溶解性	Soluble in ethanol (20 mg/ml), DMSO, methanol, and water (partly miscible).
存贮条件	储存温度2-8℃

描述

应用	Useful as a laser dye and to have selective cell growth effects. Mitochondrial specific fluorescent dye and substrate for P-glycoprotein.
产品介绍	Rhodamine 123 is a cationic dye that emits a green fluorescence. Research observations indicate that Rhodamine 123 can be used to probe the electrochemical gradient in mitochondria, in flow cytometry to detect the activity of P-glycoprotein efflux, and as a compound for P-GP mediating transport. Studies report that Rhodamine 123 can decrease the clonal growth of carcinoma cells in vitro, and that it can associate with placental P-gp. Rhodamine 123 is a substrate of Mdr (P-glycoprotein). Rhodamine 123 is a substrate of MRP1.
生化机理	Fluorescent dye most commonly used in flow cytometry as functional reporter for Pgp. Functional assays for MDR proteins are better prognostic indicators in cancer therapy than levels of MDR protein expression. Rh 123 can be used in multiparameter analyses without fluorescence interference in combination with common protein labeling dyes such as PE-Cy5 and AMCA (7-amino-4-methylcoumarin-3-acetic acid). Recent reports indicate Rh 123 may also be a substrate of MRP1.
别名	2-(6-氨基-3-亚氨基-3H-呫吨-9-基)苯甲酸甲酯;2-(6-Amino-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester

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