耗材描述

• 分子式 C₉₆H₁₈₄N₃O₂₂P
• 分子量1763.47
• Beilstein号
• EC号
• MDL号
• PubChem编号

属性

存贮条件

储存温度：-20℃

描述

应用	MPLA has been used: · as a component of cobalt porphyrin-phospholipid (Co-PoP) liposomes for the immunization of mice with membrane proximal external region (MPER) of the gp41 envelope protein · as an adjuvant along with dimethyldioctadecylammonium bromide(DDA) for C. muridarum recombinant membrane protein based multi-subunit vaccine · as toll-like receptor-4 (TLR4) agonist adjuvant for respiratory syncytial virus (RSV) fusion (F) protein FI-RSV vaccine
产品介绍	Monophosphoryl lipid A (MPLA) is either extracted from bacterial lipid A or by chemical synthesis.通过在感染前产生病原体特异性免疫应答，接种疫苗被公认为预防感染的有效方法。通常，单独使用疫苗抗原进行免疫接种并不能够诱导稳健或持久的免疫反应——导致抵抗感染的保护性免疫失败。因此，需要佐剂增强免疫后的细胞或体液免疫应答。
生化机理	Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. MPLA used in vaccination improves B cell and T cell-mediated immunity
别名	磷酸化六酰基二糖；吡喃葡糖苷脂类 A；GLA ;MPLA ；GLA

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