耗材描述

• 分子式 C₄₇H₉₄N₃O₁₉P₃
• 分子量1096.385
• Beilstein号
• EC号
• MDL号
• PubChem编号

属性

存贮条件	储存温度 -20°C

描述

产品介绍	尽管PI(4,5)P2只是细胞膜的一种次要成分，但它作为多种重要信号蛋白的底物扮演着关键的角色。PI(4,5)P2是IP3/DAG通路中的一种中间体，可被磷脂酶C水解以释放第二信使、肌醇1,4,5-三磷酸（IP3）和二酰基甘油（DAG）。PI(4,5)P2也是PI3-激酶的一种底物而可被磷酸化为PI(3,4,5)P3，而这是下游信号组分如蛋白激酶AKT的一种激活剂。
生化机理	Phosphatidylinositol 4,5-bisphosphate (PIP2) is a signaling phospholipid, present in the plasma membrane. It acts as a precursor for inositide 3 phosphate, diacylglycerol. PIP2 is a gating ligand for most of the ion channels. It functions as an activatory ligand for eukaryotic inward rectifier potassium (Kir) channels
别名	Brain PI(4,5)P2;Brain PI(4,5)P2； L-α-phosphatidylinositol-4,5-bisphosphate (Brain, Porcine) (ammonium salt), powder

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