| 应用 |
主要用于抗艾滋病药物（如齐多呋啶、石达呋啶）的制备
Thymidine (dT) is a pyrimidine deoxyriboside (deoxynucleoside) that upon sequential phosphorylation to deoxythymidine triphospate (dTTP) is used to synthesize DNA and the T-loop of transfer RNA. Thymidine is as substrate of Thymidine kinase EC 2.7.1.21 which phosphorylates the nucleoside with a phosphate derived from ATP. dT may be used to study the distribution, specificity and kinetics of a family of thymidine kinase(s).
Thymidine has been used:
· as a supplement in HL5-modified medium for cell culture
· to incubate cells in cell-cycle analysis
· in cell synchronization |
| 产品介绍 |
易溶于水、甲醇、热乙醇、热丙醇、热丙酮、热乙酸乙酯、吡啶、冰醋酸中，少量溶于热的氯仿中。水中溶解度:46 g/L (20°C)。
Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine. It is useful in cell synchronization during S-phase. In the salvage pathway of pyrimidines, pyrimidine phosphorylase reversibly converts thymine to thymidine. |
| 别名 |
β-胸苷(dT) ;β-胸腺嘧啶核苷;2'-脱氧胸腺嘧啶核苷;胸苷;2'-脱氧胸苷;胸腺嘧啶核苷; 1-(2-脱氧-β-D-呋喃核糖)-5-甲基尿嘧啶, 1-(2-脱氧-β-D-呋喃核糖)胸苷, 2′-脱氧胸苷, dT, 胸腺嘧啶核苷;;1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluracil;1-(2-Deoxy-β-D-ribofuranosyl)thymine;dT;Thymine deoxyriboside;5-Methyldeoxyuridine;Thymine-2-deoxyriboside (1-[2-Deoxy-beta-D-ribofuranosyl]-5-methyluracil) |
